Analytes | Pearson Correlation | P Value Adjusted for Age^{a} | P Value Testing for Interaction^{b} | ||
All Patients (N=95) | Age <43 (N=48) | Age ≥43 (N=47) | |||
Creatinine (µM) | 0.12 | 0.09 | 0.15 | 0.25 | 0.74 |
Osmolality (mmol/kg) | 0.06 | 0.10 | 0.005 | 0.59 | 0.49 |
Protein/creatinine ratio | 0.20 | 0.43^{d,e} | 0.05 | 0.06 | 0.03^{d} |
Protein/osmolality ratio | 0.19 | 0.32^{c,d} | 0.12 | 0.07 | 0.11 |
Lactate/creatinine ratio | 0.13 | 0.10 | 0.16 | 0.23 | 0.41 |
Lactate/osmolality ratio | 0.11 | −0.05 | 0.27 | 0.27 | 0.14 |
Pyruvate/creatinine ratio | −0.01 | 0.17 | −0.19 | 0.96 | 0.98 |
Pyruvate/osmolality ratio | −0.01 | 0.06 | −0.07 | 0.99 | 0.20 |
Lactate/pyruvate ratio | 0.08 | −0.02 | 0.17 | 0.45 | 0.99 |
Succinate/creatinine ratio | −0.08 | −0.25 | −0.02 | 0.41 | 0.68 |
Succinate/osmolality ratio | 0.01 | −0.24 | 0.18 | 0.92 | 0.13 |
cAMP/creatinine ratio | −0.11 | −0.03 | −0.17 | 0.29 | 0.87 |
cAMP/osmolality ratio | −0.08 | −0.17 | −0.004 | 0.43 | 0.22 |
PKM2/creatinine ratio | 0.28^{d,e} | 0.46^{d,e} | 0.11 | 0.006^{d} | 0.10 |
PKM2/osmolality ratio | 0.22^{c,d} | 0.41^{d,e} | 0.12 | 0.03^{d} | 0.10 |
PDK1/creatinine ratio | −0.14 | −0.12 | −0.15 | 0.19 | 0.98 |
PDK1/osmolality ratio | −0.05 | −0.11 | −0.03 | 0.61 | 0.56 |
LDHA/creatinine ratio | 0.23^{c,d} | 0.23 | 0.24 | 0.02^{d} | 0.32 |
LDHA/osmolality ratio | 0.22^{c,d} | 0.16 | 0.30^{c,d} | 0.04^{d} | 0.13 |
htTKV, height-adjusted total kidney volume; PKM2, pyruvate kinase M2; PDK1, pyruvate dehydrogenase kinase 1; LDHA, lactate dehydrogenase A.
↵a P value from multivariable regression analysis testing association between each biomarker and htTKV while adjusting for age.
↵b P value formally testing interaction by age: significant P value indicates there is evidence that the strength of the relationship between a biomarker and htTKV differs significantly depending on the patient’s age.
↵c Denotes Pearson correlation with P<0.05.
↵d Denotes significant P value.
↵e Denotes Pearson correlation with P<0.01.