I want a reverse survival horror game where a Lone Man With an Axe is trying to build his way to survival in a hostile environment, but you're the hostile environment and the dude is the enemy. So you're sending over ghosts to harass him and idk squirrels to steal supplies and maybe figure out his crafting recipes to know what resources you can keep away to mitigate the most damage. The AI on the Lone Dude would be fucking insane which is why I assume this isn't a real game yet. The goal is killing him before he finishes his portal and summons his Minecraft friends or something. I don't know, just spitballing here.
A combat game where your only form of defense is literal face-tanking. In particular, the rest your character's body is basically one-hit KO.
It wouldn't work if you tried to use a dynamic AI. It'd change the genre but if you scripted things you could make a kind of puzzle out of it.