Commentators on YouTube have pointed out that Vriska's repeated insistence of her femininity to someone who wasn't questioning it in PQ can, due to the trope Suspiciously Specific Denial, come off less like her being a trans girl and more like a closeted trans boy, and I really want to use that idea for something.
Reviving this thread to let the world know that my sibling has discovered that there is a whole sub-subgenre of isekai where the isekai-ee is a man who gets reincarnated as a cute girl and this gender-swap has absolutely zero impact on the entire rest of the thing except that all the isekai waifu stuff is F/F now, and they are deriving immense entertainment from this.
transmasc Hua Cheng.......... actually this one is totally canon compliant and really fits in with his whole "rebuilding myself into the kind of person I choose to be" deal. to me it is now canon
Dankovsky is, of the three player characters, the science guy. His in-game epithet of "The Bachelor" is because he's a bachelor of medicine, the only one with an actual degree. He's a celebrity researcher whose mission in life is to find a way to defeat death itself, and the only reason he's in the town at all is because he heard rumors that the local patriarch is more than 200 years old, and he hopes that showing that this is possible would vindicate his work as more than a pipe dream and stop his lab from being shut down. This is a very imminent risk, because the Powers That Be hate him. Danko hates them back, and considers it almost a moral duty for humanity to challenge the limitations put on them by the universe, which is why he ends up aligned with the Utopians, who think the most important thing in the town to protect is the magical structure that allows dreams, fantasies, and abstractions to become real. He's a bit of a bitter misanthrope who wants to strangle half the town for constantly getting in the way of him trying to save them from the plague with bullshit infighting and superstition, but he also cares a lot, because you can't make it through an experience like Pathologic unless you do. Everything about why he is the way he is makes so much sense if you imagine that he moved on to defeating death after he'd already experienced humanity's ability to defeat gender.