I do Dark Souls or Bloodborne when I'm listening to audio. Because I'm weird. But for me those games are very automatic. I know them very well so I don't have to think or focus as much to play them. I'd pick something like that. Something you have down to a science.
When it comes to the Coli-turns out there's another build that might be better than the Mire-flyer. It's a weird build-there's a healer with Rally, and a warrior with high Defense. It's meant to train fodder to level 10 in the Golem Workshop.