Well, I'm a fairly clean person, but I still get overwhelmed by huge tasks, so I'll try to help a bit if I can. Large tasks can seem overwhelming. If I think to myself "I have to clean the kitchen." it's a really daunting task. But if I think of it in parts as I go like "I have to wash the dishes." "I have to clean the counters." "I have to sweep the floor." "I have to mop the floor." and so on it puts it in the perspective of a bunch of smaller tasks and is less daunting. It also means if I run out of energy at cleaning the counters, I can make a mental or physical note that tomorrow I should sweep and mop. Ask for help on large projects if you can. Keeping things clean is easier to do solo than cleaning up a giant mess is. Obviously some people feel really guilty about asking for help, in which case you don't have to push yourself too much on this. Just if you have a close friend or family member who'd be willing to sit in your room with you and help you sort your stuff, it will get done faster. If you have a lot to sort through and find yourself with a lot of stuff you feel bad to throw away, consider giving it away instead if it's stuff in decent condition. Throwing things into the trash feels a lot worse than giving things to a friend or taking a box over to Goodwill does. Take breaks and reward yourself. Set reasonable goals, either by task or area or just time. Say you'll clean for 30 minutes, and then once you do so, take a break for a few. Eat a snack that you enjoy. Tell yourself that once you clean x amount of your room, you'll treat yourself to a movie or a bath or anything you'd like. Things like that. Prioritize unsanitary stuff in your cleaning. Your dirty clothes can sit on the floor for while and not really do much to hurt your health, but if you have old food containers, a clogged toilet, a cat box overflowing with poop, and so on, those tasks are the ones that need to be taken care of first. Take care of them one at a time, and make sure to take breaks if you are dealing with anything seriously dirty or smelly. Properly ventilate the area you are cleaning. Wear a dust mask if necessary. Rest if you feel ill. Do stuff as you do other stuff. I'll often empty the dishwasher or wash a few pots and pans while waiting for water to boil or something to finish up in the oven since I'm in the kitchen anyway. When it comes to cleaning your bedroom, put something on in the background that won't distract you too much. I'd recommend just something like music or an audio book, since a video or TV will potentially grab your attention and leave you sitting there and not cleaning. Unless it's the opposite for you in which case, do what works best for you. Clean stuff up as it gets messy. This will be easier to do once you've tackled your current major cleaning needs, but it's a good way to keep things clean once you've done that. For example, if I cook something and just pile stuff up as it gets dirty and then go eat, it will likely sit there. If I toss the spoons in the dishwasher as they get dirty, if I wash the pan I browned the meat in when everything is boiling together in the pot, if I wash the last of the dishes while waiting for my food to cool, I have less stuff piled in the sink to sort through and clean. This relies a lot on the other people in your life, but talk to the people you live with. Explain that you have x y z going on and it keeps you from being as clean as they might like you to be. Work with them to figure out a way that you can at least get some things done, whether it's a very clear cut with everything broken down chores list or what have you. As some anecdata here I live with someone who is very very messy. I also live with another person who has multiple sclerosis and often can't clean up his messes due to his health. I don't mind having to clean up after my housemate with multiple sclerosis, because I understand that he is limited by his health and is very often in pain, and he also does do some small things on days when he feels okay. The other housemate however has never approached any of us saying anything like 'I have trouble seeing mess.' or 'I feel depressed and it makes me not care about these things' and if she did, I'd feel a lot better about cleaning up after her sometimes, and I would be happy to work with her and put up a list of things she should try to do when she can if she needed that. But as it stands, she gets incredibly angry when you ask her to wash her dishes or make sure her laundry is out of the washing machine, so it's 'easier' for my brain to jump to feeling annoyed and even hurt that she doesn't seem to care that I am always cleaning up her messes for her if I want to cook anything for myself or do my own laundry. Communication and working together can only help both your relationship(s) with the people you live with and the cleanliness of your shared spaces, but it does take all parties being open to that communication.