@ the two guye who tried to break into my fucking house a couple of hours ago: May your trousers always be too tight and your shoes pinch.
(Best used on the unpleasantly conservative, otherwise it's just an oddly specific blessing:) May all your sons find true love with muscular men, and all your daughters find success as directors of incomprehensibly-symbolic left-leaning arthouse films.
Getting into the really heavy-duty stuff, there's always "May you get all that you deserve." Works as general purpose curse, blessing, threat, and ominous prediction.
May you be satisfied with your drawing, only to realize after posting it that you made a major unfixable error.
May you find the perfect fic of your OTP with that plot that you never knew they wanted, and may it have last updated in 2012.
May you always find the things you want to stream... exclusively on websites that require you to input payment information before you can access it.